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Sotgiu S, Zanda B, Marchetti B, Fois ML, Arru G, Pes GM, et al

This structure-based recognition, rather than sequence-based recognition, allows broader flexibility in the protein sequence between SUMO and the protein of interest

As noted by Akbarzadeh et al

Lastly, the models were trained and tested on American and Caucasian-skewed cohorts, and future studies should assess the generalizability of the findings in more ethnically and geographically diverse populations