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350 However, the protective effect of high-fiber diet may be reversed if there exists colonization of Prevotella copri , which leads to the overproduction of organic acids, including fumarate and succinate, during the digestion of complex fibers and the promotion of proinflammatory responses in macrophages, exacerbating arthritis in an RA model

32 As previously explained, the mediator Akt is also demonstrated to activate mTOR, allowing beta cell growth through cell cycle progression and by enhancing protein synthesis

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