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2004, Ed Masson, Barcelona Hvas AM, Juul S, Nexo E, Ellegaard J: Vitamin B-12 treatment has limited effect on health-related quality of life among individuals with elevated plasma methylmalonic acid: a randomized placebo-controlled study

Neuro Endocrinol Lett

Unexplained hypercobalaminemia, particularly levels above 1,000 pg/mL, has been associated with liver disease, kidney dysfunction, myeloproliferative disorders, and certain solid cancers in multiple large-scale studies

Standalone 5-Amino-1MQ without dietary or pharmacological caloric reduction will have more modest effects

However you will often find it paired with another growth hormone releasing peptide Ipamorelin because it elongates the Ipamorelins half-life allowing the peptides benefits to be felt by the user for up to 24 hours rather than the 5-6 hours of Ipamorelin on its own