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In a study by Zrelli et al., HTY promoted wound healingrelated responses in vascular endothelial cells, and this effect was associated with increased activity of the Nrf2 pathway

(PubMed) Allison GL, Lowe GM, Rahman K

It is bound to a family of six high-affinity insulin-like growth factor binding proteins (IGFBP-1 through IGFBP-6), with the great majority carried in a ternary complex composed of IGF-1, IGFBP-3, and an acid-labile subunit (ALS)

doi: 10.1523/JNEUROSCI.3305-11.2011

When PNP was inhibited pharmacologically by the compound immucillin H (ImmH), intracellular cleavage of NR to NAM was prevented, and NAD + synthesis was potentiated from NR both in vitro and in vivo 25