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This is a typical example of a futile cycle activated by cancer cells that is forbidden in the canonical biochemistry

Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-/Smad and Wnt/-catenin pathways

Mitochondrial inhibitors are being investigated in rational combinations with glycolysis inhibitors (simultaneous blockade of both major ATP-producing pathways), targeted therapies (exploiting metabolic vulnerabilities induced by oncogene inhibition), and immune checkpoint inhibitors (metabolic modulation to enhance T cell function) [70, 71]