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3.1.1 Novel Levodopa Formulations and Delivery 3.1.1.1 Extended-Release Levodopa Efforts to increase levodopas half-life and thereby reduce motor fluctuations and prolong ON-time have started more than 5 decades ago with the introduction of sustained and controlled-release (CR) levodopa formulations [15,16,17], however the evidence base for the efficacy of the first-generation agents has remained slim [14]

GIP was initially discovered because it inhibited the secretion of gastric acid

Overall, RRM2 promoted the growth of THCA cells and enhanced their metastatic ability, which is consistent with its negative prognostic effect on DFS in our dataset

Although these observations highlight ferroptosis activation, contributions from other regulated death pathways, such as apoptosis and necroptosis, cannot be fully excluded and warrant further investigation