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Cells were transfected with wild-type (WT) or mutant GPX4 plasmids for 48 h, lysed, and incubated with 5-PT, followed by detection via copper-catalyzed click chemistry

doi: 10.1016/0006-2952(95)02436-0 10 CapuanoA.ScavoneC.RacagniG.ScaglioneF

Consequently, various factors regulating cellular free iron levels, including iron uptake, excretion, storage and degradation, influence cellular susceptibility to ferroptosis [22]

Because of its abundance, GSH plays a key role in maintaining cellular redox homeostasis and in cellular mechanisms that protect against oxidative stress

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