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It is upregulated in many tumours (where its expression level correlates with poor prognosis) and decreasing METTL9 expression in hepatocellular carcinoma cells slows down their proliferation and ability to generate tumours in vivo as well as their invasiveness 17

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In such cases, the "lead compound" is used as a model for de novo synthesis of other chemical compounds which are designed so as to be related to the active part of the lead compound in 3D structure and distribution of charged, polar and non-polar groups

The concern was not the compound itself, but the unregulated formulations and lack of clinical oversight

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