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Presence, activity and properties of glutaredoxins are often analysed in coupled spectrophotometric reductive assays with bis(2-hydroxyethyl)disulfide (HEDS) as a non-glutathione substrate 10,11,12,15,16,17,18 or L-cysteine-glutathione disulfide (GSSCys) as a glutathionylated substrate 10,11,12,18,19,20,21 (Fig

Its clinical efficacy is recognized, and it often serves as a control standard when evaluating novel therapies (Mazurek et al., 2025)

Dornase alpha and hypertonic saline are recommended for chronic use to improve lung function and reduce pulmonary exacerbations per the 2013 CFF guidelines