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10.1111/jnc.13248 86 ManciasJ

Finally, linking data between public and private systems could enable continuous surveillance and equitable policy design

these bioactive molecules act on multiple targetsincluding EMT-related transcription factors and key signaling cascadesto effectively block epithelial-mesenchymal conversion, suppress myofibroblast activation and regulate aberrant extracellular-matrix (ECM) remodeling, thereby markedly curbing EMT progression and fibrotic disease ( Triptolide (TP), an active diterpenoid extracted from Tripterygium wilfordii Hook F, possesses anti-inflammatory, antiproliferative and immunomodulatory properties, and has been widely investigated in experimental idiopathic pulmonary fibrosis (IPF) models in recent years (102)

med.) of Marja-Lisa Berthold at RWTH Aachen University, Faculty of Medicine, Germany

184,185,203 It is important to note that because most PK-deficient patients are compound heterozygous for two different (missense) mutations, up to seven different tetrameric forms of PK may be present in such patients, each with distinct structural and kinetic properties