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The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized

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Taken together, these results strongly suggest that ZIL possesses higher biocompatibility than DMSO and has great potential for application in the life sciences

Research on aging mice has demonstrated that copper accumulation in brain capillaries is associated with reduced low-density lipoprotein receptor-related protein 1 (LRP1) expression and higher brain A levels (195)