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Changing direction rapidly, stopping suddenly, slowing down while running, landing from a jump incorrectly, and direct contact or collision, such as a football tackle, can also cause injury to the ACL

Lupus is an autoimmune condition where the immune system attacks its own tissues, and this causes, as I mentioned earlier, a multisystem inflammatory process and tissue damage in the affected organs

Furthermore, it contributes to the accumulation of mutations in genes critical for cell cycle regulation and neuroendocrine differentiation, such as TP53 , RB1 , AKT1 , BCL-2 , and c-MYC , thereby facilitating the promotion of carcinogenesis in MCC [57, 58]