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Glutathione, produced by cysteine, converts PLOOHs to phospholipid alcohols (PLOHs) via stimulating GPX4 to inhibit cell ferroptosis [75]

474 Inhibition of TLR4/NOX4 significantly improves left ventricular remodeling by inhibiting ferritinophagy, confirming the critical role of ferritin-mediated ferroptosis in the development of cardiac hypertrophy and heart failure