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In DR development, retinal ischemia and hypoxia stimulate the expression of hypoxia inducible factor (HIF-1) and trigger subsequent vascular endothelial growth factor (VEGF) signaling activation

A dual-readout sensing platform for the evaluation of cell viability integrating with optical and digital signals based on a closed bipolar electrode

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The factory starts making fewer red blood cells, and the ones it does manage to produce are oversized, poorly formed, and can't do their job properly