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doi: 10.1158/0008-5472.CAN-05-0957 96 SzlosarekPWGrimshawMJKulbeHWilsonJLWilbanksGDBurkeFet al

KEGG enrichment analysis revealed that the core pathways were primarily associated with inflammatory response and oxidative stress, including the PI3K-Akt signaling pathway, MAPK signaling pathway, Chemokine signaling pathway, Chemical carcinogenesis - reactive oxygen species, TNF signaling pathway, Th17 cell differentiation, mTOR signaling pathway, and IL-17 signaling pathway (Fig

Exclusion criteria included medical conditions that could confound neurodevelopmental or metabolic assessments (e.g., severe anaemia, vitamin D deficiency, or hyperhomocystinuria)

It is called mitochondrialderived because it is encoded by mitochondrial genetic material and is studied as part of how mitochondria may send signals that influence cellular behavior in experimental models