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The effects are very sustainable, though reversible, i.e., the skin could gradually regress to its original colour when the supplementation and supportive habits are discontinued

Anti-sickling potential of cocoa and other biological activities are shown in (Figure 2 ) below

In the presence of glucose, impairment of mitochondrial respiration lowers the cellular ATP content only slowly and even after hours still around half of the intial ATP content is present in the cells due to an upregulation of glycolytic ATP regeneration as demonstrated by accelerated lactate production [62, 134]

Regular assessments help tailor therapy to each patients needs.