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Description

Human intracellular ISG15 prevents interferon-/ over-amplification and auto-inflammation

These findings provide primary evidence for the exhaustion of CD4 + T cells by defining the inhibitory phenotype and the changes of CD4 + T-cell function during chronic HBV infection, and provide new insights into the mechanisms underlying CD4 + T-cell exhaustion, as well as novel immunological approaches for prospective therapeutic strategy for persisting HBV infection