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doi: 10.1038/mi.2014.44 94 BalmerMLMaEHBantugGRGrhlertJPfisterSGlatterTet al

One factor that may have contributed to this phenomenon is the nonlinear rate at which CDO accumulated in the HepG2/C3A cells in response to changes in extracellular cysteine levels

FIGURE 1 Pharmacokinetic Study by Single Intragastric and Intravenous Administration of Arsenic Trioxide Pharmacokinetic Profiles of Arsenic Metabolites in Plasma A total of five replicates (corresponding to five rats) were measured for each time point, and the mean concentration was used to establish the pharmacokinetic time curves

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