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Disclosures: Harsh Tevethia: Nothing to Disclose, Akhil Deshmukh: Nothing to Disclose, Ankur Jindal: Nothing to Disclose, Guresh Kumar: Nothing to Disclose, Shiv Kumar Sarin: Nothing to Disclose 2264 PATIENTS WITH CIRRHOSIS AND A HISTORY OF OVERT HEPATIC ENCEPHALOPATHY EXPERIENCED LOWER 6-MONTH ALL-CAUSE MORTALITY RATES WITH RIFAXIMIN MONOTHERAPY VERSUS LACTULOSE MONOTHERAPY Jasmohan Bajaj 1 Robert Rahimi 2 Christopher Allen 3 Zeev Heimanson 3 Robert Israel 3 Kris Kowdley 4 , 1 Virginia Commonwealth University and Central Virginia Veterans Healthcare System, 2 Baylor University Medical Center, 3 Salix Pharmaceuticals, 4 Liver Institute Northwest and Elson Floyd College of Medicine Background: Hepatic encephalopathy (HE) is associated with a poor prognosis, and data suggest that rifaximin use may improve survival

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These studies are shedding new light in the phenomenon of xenobiotics-induced toxicity and disease pathogenesis

Most clinical protocols recommend 500 to 1000 IU administered one to three times weekly