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Alternative pathway therapy for urea cycle disorders: twenty years later

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It was suggested that certain combinations, particularly at a GHK-Cu to LMW HA ratio of 1:9, appeared to have significantly boosted the synthesis of collagen IVmore so than when either compound was studied independently

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Therapeutic interventions included topical applications such as urea (1020%), tretinoin (0.0250.05%), salicylic acid (10%), glycolic acid (3570%), and trichloroacetic acid (15%), administered twice per day or at defined intervals over a period of 8 weeks to 2 months