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Agmatine is thought to improve insulin release and glucose uptake, assist in the secretion of luteinizing hormone, influence the nitric oxide signalling pathway, offer protection from oxidative stress, and is potentially involved in neurotransmission [266]

Given the recognized role of effector T-cells in the pathophysiology of psoriasis and PsA (6, 4850), the here presented study focused on examining DNA methylation patterns in CD4 + T-cells

There was no known history of diabetes, thyroid disorders, renal or liver disease, or recent infections

Vitamin B12 is critical for numerous bodily functions, including red blood cell production, nerve cell maintenance, DNA synthesis, and energy metabolism

TABLE 1 Effects of metformin on neurodegenerative disease models