cu zn-superoxide dismutase and glutathione peroxidase during aging Oxidative stress in Portuguese children with Down syndrome Several lines of antioxidant defense

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However, general proteomic techniques have identified a number of mitochondrial proteins with adducts of APAP, including ATP synthase and glutathione peroxidase27, and a mitochondrial proteomic approach using blue native PAGE showed changes in proteins such as HMG CoA synthase, accompanied by inhibition of enzyme activity after APAP treatment28

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de Alencar JCG, Moreira CDL, Mller AD, et al

Furthermore, because NAC supplementation raised RBC GSH synthesis of the HIV-infected subjects to the same rate observed in controls, it is likely that the lower rate of GSH synthesis in HIV-infected individuals is due to a shortage of intracellular cysteine rather than impairment of the GSH biosynthetic pathways