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The cytochromes involved include CYP2D6, CYP2C19, CYP2C18, the CYP3A family, CYP1A2, CYP2C9, and CYP2B6, with the first two enzymes having a higher affinity for most antidepressants than the rest of the enzymes (Koyama et al., 1997

The HDACis discussed in this review are targeting one or multiple classes, constituted of several HDAC proteins: epigenetic drugs targeting class I (HDAC1, 2, 3 and 8), class IIa (HDAC4, 5, 7 and 9) and/or class IIb (HDAC6 and 10) (Fig