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The longer-term picture is timing-dependent, since started near menopause it appears cognitively safe and may track with lower dementia risk, and the FDA removed the boxed warning, including the probable-dementia language, in 2026

2009 documented similar timelines in their photoaged-skin RCT 10

However, SAR425899 was discontinued in phase II clinical trials due to the high occurrence of gastrointestinal adverse events in the subjects [45]

Xu, C., Sun, L., Ren, F., Huang, P., Tian, Z., Cui, J., Zhang, W., Wang, S., Zhang, K., He, L., Zhang, W., Zhang, C., Hao, Q., Zhang, Y., Li, M., & Li, W