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Evidence from multiple studies indicates that the pathogenic effects of PM2.5 on cardiovascular disease and diabetes are mediated primarily through inflammation, oxidative stress, and insulin resistance, all of which are core features in the progression of NAFLD[72,73]

In nonalcoholic steatohepatitis, liraglutide can induce PINK1-Parkin-mediated mitophagy, which restricts the generation of ROS to suppress NLRP3-mediated hepatocyte pyroptosis [41]

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The detection of methylated circulating tumor DNA (ctDNA) of SEPT9 in blood is used as a screening method for colorectal cancer (CRC) (Laven-Law et al., 2024)