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The oxidative environment further disrupts mitochondrial membrane integrity, impairs ETC function and inhibits ATP synthesis, causing neuronal metabolic disorders and functional impairment (70)

(Swaminathan et al., 2017), the X-ray crystal structure of a ternary complex of NNMT bound with MNAM was elucidated, revealing that MNAM binds to the active site of NNMT, thereby impeding NAM binding and suppressing NNMTs enzymatic activity

However, its routine clinical use for this indication cannot yet be universally recommended

SURMOUNT-1: the landmark obesity trial This 72-week, randomized, double-blind, placebo-controlled trial enrolled 2,539 adults with obesity or overweight with at least one weight-related comorbidity