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Conclusions The treatment of melasma is challenging, as the spots are not cleared completely in most patients and recurrences are frequent

Dark green vegetables (e.g., spinach, broccoli, Brussels sprouts, and romaine lettuce), cereals (especially whole grains), fruits (e.g., oranges, papaya, and avocado), and legumes (e.g., chickpea, soybean, and lentil) are the major sources 1,13,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89

Therefore, compound 2 may exert broader anti-tumour effects if it also interferes with VEGFR2-mediated signalling, either directly or indirectly via EGFR-VEGFR2 crosstalk

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