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Theres a theoretical concern about the use of SAMe by people who are immunocompromised (such as those who are HIV-positive)

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Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX-4 signaling pathway

additionally, its catalytic activity regulates the LLPS of stress granules, which competes with the inflammasome for DDX3X to inhibit pyroptosis [87]

Telomere length and replicative aging in human vascular tissues