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Glorieux C, Enriquez C, Gonzalez C, Aguirre-Martinez G, Buc Calderon P (2024) The multifaceted roles of NRF2 in cancer: friend or foe

The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate

In female mice, there were dose-related increases in the incidences of pituitary gland adenoma and carcinoma, and mammary gland adenocarcinoma at all doses tested (50 to 200 mg/kg/day or 1 to 5 times the MRHD based on mg/m2 body surface area)

A 2018 study by Dr Linsemans team demonstrated that this is indeed the case

Sa forme rduite de L-glutathion (aussi abrge par GSH) est la plus active biologiquement et permet de neutraliser les radicaux libres en les transformant en molcules non toxiques