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Outcome measures like retinal catecholamine levels, thickness of retinal layers, expression of choline acetyl transferase and tyrosine hydroxylase, RGC density, expression of anti-apoptotic BCL-2, apoptosis evaluation by TUNEL assays, Caspase 3, Caspase 9 activity, structural and functional brain imaging, pattern electroretinogram, visual evoked potential measurements, and optokinetic behavioral assessments have been investigated with study designs ranging from animal model studies to case control and randomized controlled trials

Establishment of CIA animal model A CIA model was established using male SD rats (150 20 g)

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