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Wang Y, Han D, Zhou T et al (2020) Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells

The timing implication is that the rate-limiting factor is not how much carnitine is in the blood at any moment, but how much is stored inside the muscle, where the fatty-acid burning happens