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PPI analysis using the STRING database and Cytoscape software identified Fasn as a central hub gene

Vessels isolated from diabetic subjects exhibit increased superoxide production that is inhibited by diphenylene iodinium, and demonstrate increased expression of several NAD(P)H oxidase subunits (p22phox, p47phox, and p67phox) [17], suggesting that NAD(P)H oxidases are more active in diabetes

Recall Nrf2 release was observed in cases of KEAP1 deficiency [81]

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Naidu A.S., Wang C.K., Rao P., Mancini F., Clemens R.A., Wirakartakusumah A., Chiu H.F., Yen C.H., Porretta S., Mathai I., et al