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The most clinically useful research will come from prospective studies that specifically enroll autoimmune patients starting tirzepatide for metabolic indications and track autoimmune disease activity alongside metabolic outcomes

Our findings established the critical roles of SIRT2 in regulating redox balance through its desuccinylase activity on GCLC

The field is ready to move past proving this is a real condition and to start elucidating the specific relationship of ME/CFS symptoms to neuroinflammation

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Carbone, M., Duty, S