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A hyperosmolality-gated calcium-permeable channel encoded by reduced hyperosmolality-induced [Ca 2+ ] i increase1 (OSCA1) was identified as an osmotic stress sensor (Yuan et al., 2014), but the role of OSCA1 in the sense of high salinity-triggered osmotic stress is questioned (Zhao et al., 2020)

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Drinking alone or in secret Drinking to cope with stress or emotions Developing a tolerance to alcohol means needing more to feel the same effects