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It has been reported that first-degree relatives of patients with IBD have abnormal intestinal permeability 97 , but it is still unclear whether individuals are genetically pre-disposed to compromised barrier integrity or if diet or environmental factors make them susceptible to the disease

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By targeting the HGF/c-Met axis rather than the conventional BDNF/TrkB pathway, it opens an entirely separate avenue for investigating synaptic repair and cognitive restoration

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Axis (C2) : Provides pivot for rotation (no motion)