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Furthermore, future research should prioritize large-scale, long-term randomized controlled trials to definitively establish optimal dosing regimens, confirm sustained efficacy across diverse PCOS phenotypesespecially considering inherent heterogeneity and ethnic variations, and rigorously evaluate hard clinical endpoints such as live birth rates, prevention of T2D/cardiovascular events, and endometrial cancer risk reduction

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Exp Mol Med 57:27632781

Running therapy or antidepressants as treatments for immunometabolic depression in patients with depressive and anxiety disorders: a secondary analysis of the MOTAR study