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The age-related microglial transformation in Alzheimers disease pathogenesis

AAVrh.10-CBS uses an AAVrh.10 vector to deliver a functional human CBS gene under a cytomegalovirus early enhancer/chicken -actin promoter, targeting hepatocytes involved in homocysteine metabolism

Herein, using an established translational ex vivo model of bone in high glucose conditions, that displays structural and molecular alteration coherent with the ones observed in diabetic patients (Arajo et al