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The mechanism of GPX3 function in different types of cancers is shown in Fig

10.1016/j.jconrel.2022.09.031 87 IsmailT.CalcabriniC.DiazA

These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes