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Subsequently, the formation and bioavailability of 5-(3,4-dihydroxyphenyl)--valerolactone after intake of Pycnogenol has been demonstrated for human plasma ( ( 6.2 Systemic metabolism: conjugation and deconjugation Dietary polyphenols and microbial metabolites of procyanidins typically undergo a phase II metabolism in enterocytes and liver cells to form glucuronic acid, sulfate, and methyl conjugates (Figure 3) ( After intake of Pycnogenol , phase II conjugates of constituents and metabolites were present in plasma / serum samples (Table 3), followed by caffeic acid with 80%

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