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While data on all of these is hit or miss and inconclusive, it's best to play it safe

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doi: 10.1016/j.apsb.2016.02.001 80 HalleviH.AlbrightK

For enrollment, subjects had to demonstrate stable facial hyperpigmentation for at least 3 months, macular lesions that were neither depressed nor atrophic, and melasma severity scores of 2 or higher