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(3) While curcumin exhibits a broad spectrum of molecular targets, its pleiotropic effects complicate the elucidation of precise mechanisms of action, thereby hindering targeted therapeutic applications

The steps of the TCA cycle are as follows: (1) citrate synthase facilitates the condensation of oxaloacetate and acetyl-CoA to form citrate, (2) the enzyme aconitase then converts citrate to isocitrate, (3) isocitrate is further oxidatively decarboxylated by isocitrate dehydrogenase (IDH), (4) the resulting compound -ketoglutarate (-KG) is transformed into succinyl-CoA, (5) succinyl-CoA is then further converted to succinate by succinyl-CoA synthetase, (6) the succinate dehydrogenase (SDH) complex catalyzes the oxidation of succinate to fumarate, (7) fumarate is hydrated to malate by fumarate hydratase (FH), and finally (8) malate is then oxidized to oxaloacetate by malate dehydrogenaseinitiating the cycle once again [6] (Fig

Methylglyoxal Methylglyoxal, also known as pyruvaldehyde or 2-oxo-propanal, is an oxo-aldehyde that is generated endogenously from triose phosphate precursors during respiration (48)

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Radovanovic, Z., Djindjic, B., Dzopalic, T., Veljkovic, A., Dunjic, M., Krstic, D., Djindjic, N