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A standard deviation increase in the CognitionBrain age gap conferred a 34% increased risk ( P value meta = 1.03 10 15 ) of a clinically relevant two-point increase in the Clinical Dementia Rating Sum-of-Boxes score (CDR-SB) within five years (Supplementary Table 21)

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Cel Longev 2020, 1675613

asiatica can alleviate tubulointerstitial fibrosis caused by unilateral ureteral obstruction by downregulating the expression of Smad3 in the TGF- pathway and upregulating Smad7 protein expression with no obvious nephrotoxicity

These compounds specifically target glial inflammasome activation, effectively reducing pro-inflammatory cytokine production (270)