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The glutamatergic and dopaminergic systems are also involved in opiate tolerance and withdrawal

Radiother Oncol 18 Suppl 1:68-81, 1990

Br J Nutr 103(10):1404

To independently confirm this observation, we examined primary Atm / mouse embryonic fibroblasts (MEFs) and found that these constitutively null cells display a chronic accumulation of intracellular glutamate compared to controls (Fig