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doi: 10.1007/978-1-4939-7598-3_32

Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes

Studies suggest the prevalence of deficiency in the UK is one in 10 people aged 75 and over, one in 20 aged 65-74, and lower in younger age groups except for vegans, where prevalence is around 11%