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In Phase II results , adults taking the two highest doses lost about 16% more body weight than those on placebo after 44 weeks

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In my clinical experience, patients with tendinopathy lasting 6-24 months often report: Significant pain reduction by week 2-3 Improved load tolerance during physical therapy by week 4-6 Return to prior activity levels (with appropriate rehab) by week 10-14 Ligament Injuries Partial ligament tears (ankle sprains, knee MCL/LCL sprains, wrist sprains) often leave residual instability and chronic pain

American association of clinical endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity