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Finally, the source code (written in R) underlying the bioinformatic analysis is available in a public repository ( to foster transparency and reuse in the spirit of open science and reproducible research 69

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However, a recent phase II clinical trial evaluating the efficacy of selonsertib combined with prednisolone in the treatment of SAH patients showed no improvement in liver function or mortality compared with prednisolone alone (Mathurin et al., 2018)

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doi:10.1186/1471-2377-11-139 Tirouvanziam R, Obukhanych TV, Laval J, Aronov PA, Libove R, Banerjee AG, Parker KJ, O'Hara R, Herzenberg LA, Herzenberg LA, Hardan AY: Distinct plasma profile of polar neutral amino acids, leucine and glutamate in children with autism spectrum disorders