Abbreviations ACAN: Aggrecan ADMSCs: Adipose mesenchymal stem cells AF: Annulus fibrosus AFSCs: Annulus fibrosus stem cells BMP: Bone morphogenetic protein BMSCs: Bone marrow mesenchymal stem cells CEPs: Cartilaginous endplates CESCs: Cartilage endplate stem cells COL I: Collagen type I CPCs: Chondrogenic progenitor cells DDDs: Degenerative disc diseases DHI: Disc height index ECM: Extracellular matrix EPO: Erythropoietin ESCs: Embryonic stem cells Exos: Exsomes GDF: Growth differentiation factor GDF-5-hIPSCs: GDF-5-transfected human IPSCs HA: Hyaluronic acid hTIMP: Metalloproteinase tissue inhibitor IDD: Intervertebral disc degeneration IFN: Interferon IL: Interleukin IPSCs: Induced pluripotent stem cells IVD: Intervertebral disc IVDSCs: Intervertebral-derived stem cells MAPK: Mitogen activated protein kinase MMPs: Matrix metalloproteinases MSCs: Mesenchymal stem cells MSCs-SEVs: Derived small extracellular vesicles NCs: Notochord cells NP: Nucleus pulposus NPSCs: Nucleus pulposus stem cells PGE: Prostaglandin E PSCs: Pluripotent stem cells SAG: Smoothened agonist Shh: Sonic hedgehog TBT: Transgenic BMSCs TEC: Tissue engineering structure TNF: Tumor necrosis factor UCMSCs: Umbilical cord mesenchymal stem cells WJMSCs: Wharton's Jelly mesenchymal stem cells References Batti MC, Joshi AB, Gibbons LE
Protein-containing fractions were analyzed by sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) and western blot using an anti-histidine antibody (A7058, Sigma Aldrich)
Phytocannabinoids may act in concert with terpenes, flavonoids, and other minor compounds to modulate pharmacological responses through additive or synergistic interactions, potentially enhancing efficacy while improving tolerability (6, 7)
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