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8.2 Summary of RCTs Early studies using low-dose NAC (200 mg TID) showed no significant benefit over placebo in PEFR, weight, antibiotic use, cough, sputum viscosity, or symptom perception (102)

Immunosuppressants such as mycophenolate mofetil and azathioprine reduce disease activity but carry risks of serious infections, liver toxicity, and malignancy

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Furthermore, direct vein injury, thrombosis, thrombocytopenia, and prolonged bleeding were all counteracted (Vukojevic et al., 2018