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Materials and methods Placental tissue collection Informed consent was obtained from all clinical subjects, and placental collection was conducted in accordance with the ethical guidelines of the University of Toronto Faculty of Medicine and Mount Sinai Hospital by the Placenta BioBank, Mount Sinai Hospital, Toronto

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Changes in mitochondrial structure and morphology have also been observed, such as increased mitochondrial membrane density, decreased or disappeared mitochondrial cristae, and ruptured outer mitochondrial membranes (153)