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Many parents are reassured to know that a fever can only cause brain damage if it goes about 108 degrees F (42.22C).[17] To better understand he value of fevers, check out this page from Seattle Childrens Hospital

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Hypothyroidism (underactive thyroid): The thyroid gland is unable to produce thyroid hormone in sufficient quantities, which can cause a host of symptoms, including fatigue, muscle weakness, increased cold sensitivity, constipation, dry skin, weight gain, puffy face, hoarseness, elevated blood cholesterol, muscle aches, swollen joints, thinning hair, depression, impaired memory, slowed heart rate, and heavier than normal or irregular menstrual periods

Pagan, J

These results demonstrate the essential and direct role of P-gp in tamoxifen collateral sensitivity, while excluding the role of other cellular proteins